The Validity of Determinations of the Colloid Osmotic Pressure of Serum
نویسنده
چکیده
Measurement of the colloid osmotic pressure of the blood, or argument depending thereon, has been involved in much recent work on the origin of tissue fluid from the blood through capillary walls and in work on changes taking place in the blood due to various causes. It may be sufficient to mention Krogh (1929), Landis (1925-26, 1927, 1930, a, 1930, b), Loewen, Field, and Drinker (1931), Meyer (1931, a) and Clark and Helling (1931). The colloid osmotic pressure of the blood has been found of especial significance in edema formation (Govaerts, 1924, 1927; Schade and Claussen, 1924; Schade et al., 1926; Kylin and von Pein, 1931; Meyer, 1931, b; Iversen and Nakazawa, 1927; Meulengracht, Iversen, and Nakazawa, 1928; and others). It, therefore, becomes increasingly necessary to obtain valid and workable methods for measuring colloid osmotic pressure. Two relatively simple methods described by Krogh and Nakazawa (1927) have been much used. They, like other methods for this purpose, involve the use of artificial membranes and t,he objection has been raised that the colloid osmotic pressure obtained by such laboratory methods is not the same as the colloid osmotic pressure we would like to measure, that effective in the capillaries, because the membrane of the capillary wall and the artificial membranes used in the laboratory are very unlike, and especially it is claimed they ma,y be fatally unlike in that the electrical properties of the membranes may invalidate the readings secured by their use. While it is obviously true that the actual osmot,ic conditions
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